Updated that Chrome v85 is now out.
Chrome 85 now includes UI to enable DNS over HTTPS. To enable it:
Go to chrome settings (you can also go to chrome://settings/security and skip to step 3)
Find the Privacy and security section, then go to Security
Scroll down to Use Secure DNS and enable it, then select Custom and then Cloudflare (188.8.131.52)
You can see that it’s enabled by visiting https://184.108.40.206/help and seeing that Using DNS over HTTPS (DoH) is Yes. Note that this will only show if you’re using Cloudflare’s own DNS over HTTPS; if you set your DNS to Google or another DoH provider, CF or any other resolver can’t detect that you’re using it.
If you instead want to use 220.127.116.11/18.104.22.168 for malware/family site protection, select custom and enter the following:
https://security.cloudflare-dns.com/dns-query for malware
https://family.cloudflare-dns.com/dns-query for family
You can always find up-to-date URLs at https://developers.cloudflare.com/22.214.171.124/126.96.36.199-for-families/setup-instructions/dns-over-https/